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AB 163

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names：
Bis(2,2-dimethyl-1-aziridinyl)phosphinic acid ethyl ester
CAS號：
14984-65-7
MDL Number：
MF(分子式)： C10H21N2O2P MW(分子量)： 232.2638
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	AB 163
英文別名	AB 163; AB163; AB-163; NSC 108878; NSC-108878; NSC108878
CAS號	14984-65-7
Inchi	InChI=1S/C10H21N2O2P/c1-6-14-15(13,11-7-9(11,2)3)12-8-10(12,4)5/h6-8H2,1-5H3
InchiKey	SOYAWOSQURUWHG-UHFFFAOYSA-N
分子式 Formula	C10H21N2O2P
分子量 Molecular Weight	232.2638
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產品說明	AB 163(CAS:14984-65-7):僅限應用于工業或者科學研究過程中非醫療目的，不應用于人類或動物的臨床診斷以及治過程療，該產品非藥用，非食用。
Introduction	AB 163 is a TEPA analogue that has been tested for use in radiation therapy for patients with esophageal carcinoma; adenocarcinomas of the gastrointestinal tract; squamous carcinoma of the cervix; and adenocarcinoma of the ovary. The drug is proposed to phosphorylate X ray induced DNA strand damage, and prolongs time of the absence of disease in patients. There may side effects on the GI system and the central nervous system.
Application1
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Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護
備注

[1]Wampler GL, Wassum JA, Belgrad R. Radiation potentiating effect of ethyl bis(2,2-dimethyl-1-aziridinyl) phosphinate (AB-163). Int J Radiat Oncol Biol Phys. 1979 Sep;5(9):1681-3. PubMed PMID: 536277.

[2]Belgrad R, Wampler GL. A pilot study with ethyl bis (2,2-dimethyl-1-aziridinyl) phosphinate (AB-163) and radiation therapy. Int J Radiat Oncol Biol Phys. 1982 Jul;8(7):1219-23. PubMed PMID: 6811518.

[3] Munson AE, Babbitt H, Chmielewicz ZF, Bardos TJ, Ambrus JL. Studies on the chemistry, antitumor activity, and pharmacology of ethyl di-(2,2-dimethyl)ethylenamido phosphate (AB-163). J Surg Oncol. 1969;1(2):167-80. PubMed PMID: 5406362.

[4] Sreekumar E, Premraj A, Arathy DS, Rasool TJ. Identification, sequence characterization, and analysis of expression profiles of three novel CC chemokines from domestic duck (Anas platyrhynchos). Immunogenetics. 2005 Jun;57(5):364-73. Epub 2005 Apr 20. PubMed PMID: 15841394.

[5] Wampler GL, Kuperminc M, Regelson W. Phase I study of ethylbis(2,2-dimethyl-1-aziridinyl) phosphinate (AB-163). Cancer Chemother Pharmacol. 1980;4(1):49-52. PubMed PMID: 7363402.

6: MacDiarmid JE, Rose WC, Biddle WC, Perlman ME, Breiner RG, Ambrus JL, Bardos TJ. Synthesis and properties of bis(2,2-dimethylaziridinyl)phosphinic amides: a series of new antineoplastic agents. J Med Chem. 1985 Nov;28(11):1685-91. PubMed PMID: 4067995.7: Dunn JA, Bardos TJ. Comparative chemical and biological studies of four prototype phosphoraziridine antineoplastic agents. Biochem Pharmacol. 1991 Mar 15-Apr 1;41(6-7):885-92. PubMed PMID: 2009083.

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