購物車 
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Withanolide B
- names：
(5alpha,6alpha,7alpha,22R)-5-Hydroxy-6,722,26-diepoxyergosta-2,24-diene-1,26-dione
- CAS號：
56973-41-2
MDL Number： - MF(分子式)： C28H38O5 MW(分子量)： 454.607
- EINECS: Reaxys Number:
- Pubchem ID: Brand:BIOFOUNT
| 貨品編碼 | 規格 | 純度 | 價格 (￥) | 現價(￥) | 特價(￥) | 庫存描述 | 數量 | 總計 (￥) |
|---|
| 中文別名 | (5alpha,6alpha,7alpha,22R)-5-Hydroxy-6,722,26-diepoxyergosta-2,24-diene-1,26-dione |
| 英文別名 | Withanolide B |
| CAS號 | 56973-41-2 |
| Inchi | InChI=1S/C28H38O5/c1-14-13-20(32-25(30)15(14)2)16(3)17-8-9-18-22-19(10-12-26(17,18)4)27(5)21(29)7-6-11-28(27,31)24-23(22)33-24/h6-7,16-20,22-24,31H,8-13H2,1-5H3/t16-,17+,18-,19-,20+,22-,23+,24+,26+,27-,28-/m0/s1 |
| InchiKey | ZTEVDTFJUUJBLP-HGSBMKTESA-N |
| 分子式 Formula | C28H38O5 |
| 分子量 Molecular Weight | 454.607 |
| 溶解度Solubility | |
| 性狀 | Solid powder |
| 儲藏條件 Storage conditions | Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years). |
| 產品說明 | Withanolide B(CAS:56973-41-2):僅限應用于工業或者科學研究過程中非醫療目的，不應用于人類或動物的臨床診斷以及治過程療，該產品非藥用，非食用。 |
| Introduction | Withanolide B is a withanolide that has been found in W. somnifera. Unlike withanolide A, it does not increase glucose uptake in L6 myotubes. In in silico docking studies, withanolide B was identified as a neuronal nitric oxide synthase (nNOS) inhibitor that also inhibited inducible NOS (iNOS) and endothelial NOS and as a ligand for the PARP1 catalytic domain. |
| Application1 | |
| Application2 | |
| Application3 |
| [1]Ben Bakrim W, El Bouzidi L, Nuzillard JM, Cretton S, Saraux N, Monteillier A, Christen P, Cuendet M, Bekkouche K. Bioactive metabolites from the leaves of Withania adpressa. Pharm Biol. 2018 Dec;56(1):505-510. doi: 10.1080/13880209.2018.149978[1]PubMed PMID: 30451050; PubMed Central PMCID: PMC6249549. |
| [2]Dubey S, Kallubai M, Sarkar A, Subramanyam R. Elucidating the active interaction mechanism of phytochemicals withanolide and withanoside derivatives with human serum albumin. PLoS One. 2018 Nov 7;13(11):e0200053. doi: 10.1371/journal.pone.0200053. eCollection 2018. PubMed PMID: 30403672; PubMed Central PMCID: PMC6221254. |
| [3] Hussain H, Csuk R, Green IR, Ur Rehman N, Abbas G, Hussain W. Journey Describing the Cytotoxic Potential of Withanolides: A Patent Review. Recent Pat Anticancer Drug Discov. 2018;13(4):411-421. doi: 10.2174/1574892813666180808154928. Review. PubMed PMID: 30091418. |
| [4] Mishra A, Singh SP, Mahfooz S, Bhattacharya A, Mishra N, Shirke PA, Nautiyal CS. Bacterial endophytes modulates the withanolide biosynthetic pathway and physiological performance in Withania somnifera under biotic stress. Microbiol Res. 2018 Jul - Aug;212-21 |
| [5]17-28. doi: 10.1016/j.micres.2018.04.006. Epub 2018 Apr 22. PubMed PMID: 29853165. |
5: Yang L, Meng X, Kuang H. Comparisons of the pharmacokinetic and tissue distribution profiles of withanolide B after intragastric administration of the effective part of Datura metel L. in normal and psoriasis guinea pigs. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Apr 15;108
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