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Theophylline hydrate

NMR下載 COA and HPLC MSDS下載
names：
1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione hydrate
CAS號：
5967-84-0
MDL Number：
MF(分子式)： C7H10N4O3 MW(分子量)： 198.18
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文別名	1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione hydrate
英文別名	Theophylline; Theoclear-200; Theo-24; T-Phyl; Aerolate JR;
CAS號	5967-84-0
Inchi	InChI=1S/C7H8N4O2.H2O/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;/h3H,1-2H3,(H,8,9);1H2
InchiKey	INQSMEFCAIHTJG-UHFFFAOYSA-N
分子式 Formula	C7H10N4O3
分子量 Molecular Weight	198.18
溶解度Solubility
性狀	Solid powder
儲藏條件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

產品說明	Theophylline hydrate(CAS:5967-84-0 ):僅限應用于工業或者科學研究過程中非醫療目的，不應用于人類或動物的臨床診斷以及治過程療，該產品非藥用，非食用。
Introduction	Theophylline is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE that degrades CYCLIC AMP thus potentiates the actions of agents that act through ADENYLYL CYCLASES and cyclic AMP.
Application1
Application2
Application3

警示圖
危險性	Warning
危險性警示
安全聲明
安全防護
備注

[1]Barnes PJ. Theophylline. Am J Respir Crit Care Med. 2013 Oct 15;188(8):901-6. doi: 10.1164/rccm.201302-0388PP. Review. PubMed PMID: 23672674.

[2]Pacifici GM. Clinical pharmacology of theophylline in preterm infants: effects, metabolism and pharmacokinetics. Curr Pediatr Rev. 2014;10(4):297-303. Review. PubMed PMID: 25594527.

[3] Fernández-Campos F, Ferrero C, Colom H, Jiménez-Castellanos MR. Invivo absorption behaviour of theophylline from starch-methyl methacrylate matrix tablets in beagle dogs. Int J Pharm. 2015 Jan 30;478(2):684-92. doi: 10.1016/j.ijpharm.2014.11.071. Epub 2014 Dec 2. PubMed PMID: 25476254.

[4] DuBois B, Louey S, Giraud GD, Cherala G, Jonker SS. Theophylline Pharmacokinetics in Foetal Sheep: Maternal Metabolic Capacity is the Principal Driver. Basic Clin Pharmacol Toxicol. 2015 Oct;117(4):226-33. doi: 10.1111/bcpt.12395. Epub 2015 Mar 19. PubMed PMID: 25728792; PubMed Central PMCID: PMC4750914.

[5] Voynikov Y, Valcheva V, Momekov G, Peikov P, Stavrakov G. Theophylline-7-acetic acid derivatives with amino acids as anti-tuberculosis agents. Bioorg Med Chem Lett. 2014 Jul 15;24(14):3043-5. doi: 10.1016/j.bmcl.2014.05.026. Epub 2014 May 17. PubMed PMID: 24878196.

6: Chae JW, An JH, Kang W, Ma Jy, Kwon KI. Effect of decursinol angelate on the pharmacokinetics of theophylline and its metabolites in rats. Food Chem Toxicol. 2012 Oct;50(10):3666-72. doi: 10.1016/j.fct.2012.06.049. Epub 2012 Jul 4. PubMed PMID: 22771369.7: Aswini KK, Vinu Mohan AM, Biju VM. Molecularly imprinted poly(4-amino-5-hydroxy-2,7-naphthalenedisulfonic acid) modified glassy carbon electrode as an electrochemical theophylline sensor. Mater Sci Eng C Mater Biol Appl. 2016 Aug 1;6

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